Objective: To examine the frequency of exclusive breastfeeding in the Vukovar-Srijem County. Study design: A cross-sectional study was conducted. Respondents and methods: 302 respondents from the Vukovar-Srijem County participated in the research. The survey was conducted using an anonymous questionnaire, conducted online in Google Forms from February to April 2021. Results: The results found that there is a significant statistical correlation between exclusive breastfeeding and place of residence, age and as well as education so that women with higher academic education in urban areas exclusively breastfeed longer compared to women from rural areas and secondary education. No significant statistical correlation was found between exclusive breastfeeding and marital status, household coexistence, number of children and attending a pregnancy course. Also, this study found that the most common reason for stopping exclusive breastfeeding before the sixth month of a child's life is most often due to mastitis, poor weight progression, and return to work. Conclusion: These results indicate the need for better promotion and information about the benefits of exclusive breastfeeding, for both mother and child. Among professional medical staff, the nurse is in the most direct contact with mothers or pregnant women. The trust that can develops in frequent and direct meetings between the nurse and the mother should be one of the foundations for a more successful acceptance of expert advice on breastfeeding. The role of the nurse is significant on all three levels of health care delivery. One of the most important tasks in this period is the promotion of breastfeeding, education on the benefits of breastfeeding and education on proper nutrition for both mother and child.