The objective of the research: To examine the relationship between job satisfaction, professional quality of life, and burnout at work with physiotherapist demographics. Study Design: A cross-sectional survey was conducted from December 2021 to the end of February 2022. Participants and methods: 404 physiotherapists participated in the study. The data was collected through an online questionnaire based on an invitation sent through groups on social networks specializing in physiotherapists. The questionnaire consisted of four parts. The first part included general demographic data. The second part measured satisfaction with the job of a physiotherapist. The third part assessed professional quality of life, and the fourth part measured the burnout of a physiotherapist. Results: 404 physiotherapists participated in the study, of which 84.9% were women. Most physiotherapists have completed an undergraduate degree in physiotherapy (59.2%). Half of the physiotherapists (50.3%) work in the private sector. Physiotherapists are most satisfied with their associates and least satisfied with the management staff. They feel professional satisfaction at work and consider their work positive, without major traumatization. Respondents showed moderate levels of disengagement, exhaustion, and burnout syndrome. Those physiotherapists who are satisfied with their job have less pronounced levels of burnout at work and are less susceptible to traumatic stressors. Greater job satisfaction also results in less distance from work and less exposure to stress. Older physiotherapists are less satisfied with their job and are more susceptible to secondary traumatization. Physiotherapists employed in the private sector are more satisfied with their supervisors, the job itself, and the salary, and they are more compassionate. Conclusion: Physiotherapists working in the private sector and those in the partnership are most satisfied with their job. Women are more satisfied with their job and have a higher professional quality of life, while burnout at work is equally pronounced in both sexes. Younger physiotherapists are the most satisfied with their job, and the older ones are the least satisfied with their job and have a higher risk of professional burnout.