Title: Strategies for coping with stress in relation to personality traits in employees of the Department of Emergency Medicine of Osijek-Baranja County Objectives: The primary objective of this study was to determine stress coping strategies, in correlation with personality traits among employees of the Department of Emergency Medicine of Osijek-Baranja County (DEM-OBC), as well as to examine coping strategies in relation to age, sex, qualification, and place of work. Study design: This research was designed as a cross-sectional study. Subjects and methods: 102 DEM-OBC employees were included in the study, between January and April 2022. The goal of the study was explained verbally and in writing to each participant through informed consent. The IPIP-50 questionnaire, the personality traits questionnaire, in a version adapted to the Croatian language, and the Sorić and Proroković questionnaire on coping with stressful situations were used. Results: Of the 102 subjects, 25 are physicians, 47 are nurses/technicians, and 30 are drivers, of whom 63.7% are men and 36.3% are women. Of the personality trait domains, intellect has the highest median value of 34, while emotional stability has the lowest value of 26. The highest median value of the stress coping domain is active coping and is 63, and the lowest median value of 18 is social distraction. The P-value of 0.001 when comparing intellect and active coping confirms the positive correlation, as does the P-value when comparing extroversion and agreeableness with social distraction. Conclusion: A positive association of extroversion and agreeableness with social diversion was observed, followed by emotional stability with active coping, and the most pronounced association is that of intellect with active coping. The most pronounced domain of the personality trait is intellect, and the least pronounced is emotional stability. The most salient domain of stress coping is active coping, and the least salient is social diversion. No significant correlation was found in the stress coping domain between sex and workplace.