Aim: Examine the level of awareness among nurses about the importance of self-examination of the skin and to investigate the awareness level in relation to age, gender, level of education, and workplace. Study design: Cross-sectional research. Participants and Methods: The study was conducted at the University Hospital Centre Osijek, including the Department of Oncology, the Department of Dermatology and Venereology, and the Clinic for Surgery during March and April 2024. The participants were nurses and medical technicians, with 105 participants in total. Data was collected using an anonymous questionnaire designed specifically for this thesis, which contained 20 questions with simple multiple-choice answers. Results: Statistically significant associations were found between participants' age and adherence to medical advice on skin protection and wearing protective clothing in the summer. Gender was significantly associated with performing skin self-exams, the frequency of self-exams, noticing changes in the skin and moles, reading educational materials, using sunscreens with SPF, and knowledge about the risks of tanning beds. Length of employment showed a significant association with noticing changes in the skin, adherence to skin protection advice, and wearing protective clothing in the summer. Conclusion: Women, compared to men, are more likely to perform self-examinations of their skin, notice changes in their skin and moles, read educational materials on proper skin protection, use creams with SPF, and are aware of the risks associated with tanning beds. Respondents aged 46 to 65 years, as well as those with more than 21 years of work experience, are significantly more likely to notice changes in their skin, follow medical advice, and wear protective clothing.