Objectives: To examine the opinions and the knowledge of Nursing students about people with physical disabilities, to examine the differences in knowledge and opinion considering whether they are employed in the profession or outside of it, and considering their years of work experience. Study design: Cross-sectional study. Respondents and methods: 121 students of undergraduate and graduate study programme of Nursing at the Faculty of Dental Medicine and Health Osijek participated in the research. The survey was conducted using the original questionnaire "Attitudes Toward Disabled Persons (ATDP) Form O", translated into Croatian. Results: The research revealed significant differences in the knowledge and the opinions of respondents considering employment and work experience. Students employed outside their profession showed better knowledge and a more positive opinion. Respondents with more years of work experience showed better knowledge, but a more negative opinion compared to students with less or no work experience. The results indicate a high prevalence of negative opinion when it comes to the inclusion of people with physical disabilities in the community or when it comes to examining the character traits of people with physical disabilities. Conclusion: Health workers are responsible for providing quality and complete care to people with disabilities. The term care means care for both physical and mental health. Only a medical nurse/medical technician approaching a person with a disability with knowledge and without prejudice can do their job at a high level and help the person adapt and improve the quality of life.