Objectives: To carry out anthropological analyzes of specific pathological changes on samples of the human spine, such as Schmorl's defects, and to interpret the influence of daily life activities on their occurrence. Study Design: Cross-sectional study. Participants and Methods: The research included a total of 1,783 vertebrae, naturally mummified skeletons from the crypt of the Dominican church in Vác, Hungary from the end of the 17th to the beginning of the 19th century. The research was conducted in the Anthropology Department of the Natural History Museum of Hungary in Budapest. Standard macroscopic and microscopic anthropological methods were used. The presence of Schmorl's defects according to age and gender, spinal segment, location and position on the surface of the vertebral bodies was examined and a typology was performed. Results: A total of 474 (25.8%) cervical vertebrae, 953 thoracic vertebrae (51.9%) and 409 (22.3%) lumbar vertebrae were processed. 17.72% of vertebrae have Schmorl defects. Male vertebrae have a greater presence of Schmorl's defects. The highest frequency of Schmorl's defects is from Th 6 to L2 vertebra. Changes of type B Schmorl defects are the most common (46.15%) and most prevalent on both surfaces of the vertebral body (significantly on the medial and posterior surfaces) in both sexes, as well as in middle-aged and older adults. In the skeleton vertebrae of middle adulthood (40 - 59 years), there is a significantly higher proportion of vertebrae with Schmorl's defects present. Conclusion: Specific pathological changes of the human spine, Schmorl's defects, are present on samples of Vác mummies from the new era. Anthropological analyzes included the typology of Schmorl's defects as a predictor of the impact of duration of physical load on the spine in daily life activities. The presence of Schmorl's defects in the cervical spine of these samples shows a pattern of postural adaptation to a sedentary lifestyle, as observed in modern populations.