Objectives: To examine whether there are differences between women and men in the association of anxiety arising during hospital treatment with at least one of the eight symptoms of dementia: difficulties with memory, orientation, judgment, problem solving, fulfilling social obligations, daily activities at home and with hobbies or personal care, in patients with mild to moderate dementia. Study design: A cross-sectional study was conducted at the Dementia Department of the Sveti Ivan Psychiatry Clinic in Zagreb during June 2023. Subjects and methods: The target population consisted of hospitalized patients with diagnosed dementia, both sexes and aged 60 to 90 years without psychiatric comorbidities from the schizophrenic spectrum. Anxiety during hospital treatment was measured using the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS-A), and the severity of dementia symptoms using the Clinical Dementia Rating (CDR). The hypothesis was tested by analyzing the statistical significance of the differences in the unstandardized linear regression coefficients of the HADS-A on individual symptoms of dementia, between women and men using the Wald test after adjustment for age, education, the existence of a spouse or stable non-marital partner and the duration of current hospital treatment. Results: 65 women and 35 men of comparable age were included. Between women and men, there were statistically significant differences in the association between anxiety arising during hospital treatment and difficulties with judgment (P = 0.01), fulfilling social obligations (P < 0.001), difficulties with home and hobbies (P = 0.02) and personal care (P = 0.00). Conclusion: There are differences between the two sexes in the connection between anxiety arising during hospital treatment and the severity of individual symptoms of dementia. These differences are present in difficulties with judgement, fulfilling social obligations, home, hobbies, and personal care.