INTRODUCTION: In late 2019, a new coronavirus, now called severe acute respiratory syndrome (SARS-Cov-2), was isolated for the first time in Wuhan, China. Coronavirus causes a set of acute respiratory diseases, called coronavirus disease 2019 (COVID-19). The most common reason for admitting a patient to an intensive care unit is the development of acute hypoxemic respiratory failure, which is an indication for the use of non-invasive ventilation through high-flow nasal cannulas. METHOD: A descriptive method was used to write the dissertation by searching the available databases on the Internet. The scientific databases Hrčak, Embasa, Google Schoolar, PubMed and Researchgate were searched using keywords. The inclusion criterion was the literature related to the use of high-flow nasal cannulas in the treatment of coronavirus disease, while the exclusion criterion was the literature older than 5 years. OUTLINE: The world today is facing the biggest health challenge of the 21st century caused by a virus that causes a respiratory disease called coronavirus disease 2019, or COVID-19 disease. The clinical manifestations of the disease are diverse, from asymptomatic infection to acute respiratory distress syndrome requiring admission to intensive care units with endotracheal intubation and invasive mechanical ventilation and is associated with a high risk of mortality. The High Flow Nasal Cannula (HFNC) ventilation vent is able to deliver a large flow of properly heated and moist air. It enables reliable oxygen delivery and allows an increased proportion of inhaled oxygen (FiO2), from 21% to almost 100%, preventing the dilution of oxygen by room air. The relatively small interface and physiological temperature of this therapy allow for a very high tolerance. CONCLUSION: Nurse is responsible for device preparation, preparation, and patient monitoring, with multiple daily assessments of the patient's respiratory status to avoid delaying intubation if the patient's condition worsens. The nurse must know the mechanism of action of HFNC support, its advantages and disadvantages, and the expected benefit to the patient. Likewise, the nurse will establish a confidential relationship with the patient, be available to answer all of his or her questions, and provide psychological support.