Aim of research: To examine the quality of life among people suffering from malignant diseases in Vukovar-Srijem County. Apart from this, the specific goals were to enquire whether there is a significant difference in the quality of life considering gender, age, and localization of malignant diseases. Scheme of study: In order to arrive at the results, a cross-sectional study was carried out. Data was collected through a survey from March to July 2021. Respondents and methods: Patients suffering from malignant diseases from Vukovar- Srijem County participated in the survey. They were previously informed orally and in written form regarding the aim of the research and signed their consent to participate in the research. The nurses in the mobile palliative teams of the Vinkovci Health Centre and Županja Health Centre distributed the surveys during their regular visits to the patients, that is, home healthcare visits. There were 37 questions in the survey, with 65 respondents participating. Results: The results showed that age has an influence on the quality of life among people suffering from malignant diseases, that is, if the patient is younger, he/she will have a higher quality of life than an older patient. In addition, the results showed that quality of life depends on gender. In addition, the results showed that quality of life does not depend on gender, that is, the P value does not show statistical significance. Different localizations of malignant diseases does not affect the quality of life. Conclusion: Modern medicine has advanced early diagnostics and methods of treatment for malignant diseases, which has consequently prolonged the lives of those suffering from malignant diseases. The task for all participants in the treatment process as well as family members is to direct their activities towards improving the quality of life for these patients.