Objectives: The aim of this research is to investigate the effectiveness of different wavelengths of laser radiation in the treatment of orofacial pain by measuring pain reduction using a visual analog scale (VAS). This research will provide a significant contribution to the treatment of atypical orofacial pain, especially its most common form, which is the burning mouth syndrome. Participants and Methods: 30 patients diagnosed with burning mouth syndrome were included in the study. Each patient was evaluated according to the subjective reporting of pain: 0-10 VAS. Orofacial pain was quantified by the VAS, where 0 indicated “no pain” and 10 “worst possible pain.” Patients were then treated with low level laser therapy (LLLT) 5 days per week for 4 consecutive weeks with 660 nm or 810 nm. Results: The obtained results were analyzed in two groups. The first group included 15 subjects who were treated with a 660 nm laser, while the second group of subjects consisted of a group of 15 research participants who were treated with an 810 nm laser. The parameters that were investigated was the assessment of pain before and after laser treatment. Comparison of pain sensation before and after laser therapy with a wavelength of 660 nm showed that the difference was statistically significant (z = 2.93; P = 0.003). Comparison of pain sensation before and after 810 nm laser therapy showed that the difference was statistically significant (z = 3.29; P < 0.001). Conslusion: According to today's knowledge, it is reasonable to assume that the biostimulatory effect of LLLT has a beneficial effect on the treatment of pain and the quality of life in burning mouth syndrome. Our results obtained by measuring pain using a visual analog scale show that treatment with low-energy lasers of wavelengths 660 nm and 810 nm resulted in a statistically significant reduction in pain in burning mouth syndrome. In the future, further research is certainly necessary, which would shed light on existing doubts in treatment and lead to a standardized treatment protocol.