Objectives: To examine the predictors of quality of life and depression in people suffering from multiple sclerosis, the difference between quality of life and depression with respect to the incontinence. To examine the connection of quality of life and depression with demographic variables and incontinence. Study Design: Cross-sectional research Participants and Methods: The study included 156 suffering from multiple sclerosis. The research was conducted via the use of an anonymous survey consisting 26 questions including questions on socio-demographics, incontinence, depression and quality of life. The instrument used in the reseach were: World Health Organization Questionnaire on Quality of Life and the International Society for Incontinence Questionnaire. Results: The results show that 86 % of the respondents are female. 51.3 % of the respondents have a lower level of education and 56.4 % of them are in a marital union. People with a lower level of education are more depressed. 30.8 % of the respondents do not have incontinence, 28.2 % experience it once a week, and 19.2 % experience it several times a week. More frequent incontinence and the amount of urine leaked leads to a greater occurrence of depression and lower quality of life. Females and marital union are positive predictors of the quality of life and females have a higher level of depression than males. Conclusion: People who do not have incontinence disorders have a lower level of depression and a better quality of life. More frequent incontinence and a larger amount of urine leaked in people suffering with multiple sclerosis contribute to greater depression levels and lower quality of life. People with a lower level of education are more depressed and being a female contributes to a higher level of depression. Marital union and female gender are positive predictor of the quality of life in the study group.