Introduction: Since its appearance by the end of 2019 the COVID-19 pandemic has brought with it a number of negative consequences. Nurses/technicians in the workplace are exposed to an increased risk of infection on a daily basis and thus to the risk of imposing isolation and/or self-isolation measures. Goals: To examine respondents' opinions on COVID-19 disease, the contribution of self-isolation and/or isolation and the occurrence of the pandemic to the mental health of nurses/technicians. To examine the opinion and general knowledge about COVID-19 and return to work after the measures have been imposed. Examine the impact of the onset of the COVID-19 pandemic and self-isolation and/or isolation on nurses/technicians in relation to sociodemographic data. Methods: Cross-sectional study. Anonymous and voluntary examination. Respondents of both sexes, nurses/technicians employed at the General Hospital Virovitica, a total of 91 respondents. The questionnaire consisted of five parts, a total of 60 questions. The total time required to complete the questionnaire was 15 minutes on average. Results: Of the total number of respondents 75,8% (N=69) were women and 24,2% (N=22) were men. Most respondents were in the age group of 18 to 30 years, 48,4% (N = 44). Self-isolation measures were imposed on 67,4% (N = 13) of women and 31,6% (N = 6) of men. Of the total number of respondents 58,2% (N = 53) have children. There was a statistically significant difference in the effect of stressful events on the respondents. Conclusion: Significant differences were observed in certain segments of the study. The largest proportion of respondents did not feel fear of going into self-isolation compared to those who were in isolation. Significant differences were observed by examining the occurrence of fear of conviction when returning to work after the imposed measures and in relation to the age of the respondents and whether they have children.