Introduction: As many as 17.5 million people worldwide die of cardiovascular diseases every year and 45% of all deaths in Croatia are caused by cardiovascular diseases. Aside from death, these diseases cause a large number of permanent disabilities, and all of it may be prevented by using the appropriate preventive measures implemented by a multidisciplinary team. Procedures: The procedures for writing this paper have been obtained from professional articles, books, and websites. The internet-based databases are the following: Hrčak, PubMed, Scopus, Web of Science. Topic overview: Cardiovascular diseases are among the leading causes of morbidities and mortality. Most of the risk factors are variable and can be affected. The patients’ risk factors are identified during the process of risk assessment and various interventions may be planned on that basis. The applied assessment tool is the “SCORE” table of the European Society of Cardiology. Diabetes mellitus, hypertension, and excessive weight “share” pathological mechanisms, cause vascular damage, inflammation, and disfunction of the endothelium, affect the renin-angiotensin system, and lead to macrovascular complications. Prevention guidelines are based on changing the person’s lifestyle, quitting smoking, reducing excessive body weight, physical activity, and controlling blood pressure and blood sugar and cholesterol levels. Prevention and rehabilitation are implemented by a multidisciplinary team whose education goals are focused on the patient and their family. Conclusion: Appropriate prevention may prevent a significant number of diseases and death caused by cardiovascular diseases. The key to prevention is quality education of patients, in order for them to change their lifestyle, adopt healthy habits, and reduce the risk factors for the development of diseases or complications.