Objectives: The aim of this study is to examine quality levels of therapeutic alliance between healthcare professionals and hospitalized patients. Study design: The research is designed as a cross sectional study. Participants and Methods: The research was conducted at the Clinical Hospital Center Osijek, specifically at the Clinic for Psychiatry. A total of 184 respondents participated in the study, 132 of which were hospitalized patients and 53 healthcare workers. All participants were provide d timely information regarding the research objectives and methodology, they were given relevant materials, and have given their consent to participate in the study. Material and Methods: The same general demographic questionnaire was used as a research in strument for both healthcare workers and hospitalized patients. In order to assess the quality level of the therapeutic alliance, the Scale to Assess the Therapeutic Relationship in Community Mental Health Care: STAR ““; questionnaire was applied, with aqui red permission from the authors. Results: Healthcare professionals rated positive cooperation significantly higher than patients (Fisher s exact test, P = 0.01). They also experienced more emotional difficulties in comparison to the domain of positive clin ical support for patients (Mann Whitney U test, P = 0.02). However, even though the healthcare professionals have given it a slightly higher grade, there is no significant difference in the overall assessment of the therapeutic alliance between healthcare professionals and patients. Conclusions: The results of the study indicate that both healthcare professionals and patients perceive a favorable therapeutic alliance. Positive collaboration is rated higher among the health care professionals than the patients, with them potentially experiencing more emotional challenges. On the other hand, patients grade higher the level of excellence, in terms of the positive clinical support they receive, than the healthcare professionals. However, both groups of res pondents equally recognize a high level of positive clinical support.